Nonmotor symptoms are independently associated with impaired health‐related quality of life in Chinese patients with Parkinson's disease
Identifieur interne : 000623 ( Main/Exploration ); précédent : 000622; suivant : 000624Nonmotor symptoms are independently associated with impaired health‐related quality of life in Chinese patients with Parkinson's disease
Auteurs : Huijuan Li [République populaire de Chine] ; Meifen Zhang [République populaire de Chine] ; Ling Chen [République populaire de Chine] ; June Zhang [République populaire de Chine] ; Zhong Pei [République populaire de Chine] ; Ailing Hu [République populaire de Chine] ; Qing Wang [République populaire de Chine]Source :
- Movement Disorders [ 0885-3185 ] ; 2010-12-15.
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Abstract
We performed a cross‐sectional study of 82 Chinese patients with Parkinson's disease (PD) enrolled during an 18‐month period using a clinical interview to assess the prevalence of nonmotor symptoms (NMS), the association with disease severity and motor status, and the impact on patients' health‐related quality of life (Hr‐QoL). The patients' NMS, Hr‐QoL, disease severity, and motor status were assessed by the Nonmotor Symptoms Scale (NMSS), the 39‐item Parkinson's Disease Questionnaire (PDQ‐39), the modified Hoehn and Yahr staging scale (H&Y) and the Unified Parkinson's Disease Rating Scale part III (UPDRS III), respectively. We found that 100% of patients with PD presented with NMS. The NMSS significantly correlated with disease duration (Spearman's rS = 0.276, P = 0.012), H&Y (rS = 0.230, P = 0.038), and UPDRS III (rS = 0.350, P = 0.001). Similarly, the PDQ‐39 SI significantly associated with the disease duration (rS = 0.258, P = 0.019), H&Y (rS = 0.340, P = 0.002), and UPDRS III (rS = 0.453, P < 0.001). NMS domains that influenced the PDQ‐39 SI were sleep/fatigue, mood, gastrointestinal, urinary, and miscellaneous symptoms. This strongly suggested that the five domains played a key role in the manifestation of Hr‐QoL. NMSS explains more of the variability in Hr‐QoL than UPDRS III, when both are the model (stepwise multiple linear regression analysis R2 change, 47.8% vs. 5.87%, respectively). Therefore, these findings demonstrate that NMS are independently and negatively associated with Hr‐QoL in PD and that improving NMS should be viewed as an important part in the management of PD. © 2010 Movement Disorder Society
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DOI: 10.1002/mds.23368
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Department of Neurology, Director of Neurological Research Laboratory, The Third Affiliated Hospital of Sun Yat‐Sen University, 600 Tianhe Road, Guangzhou, Guangdong 510630</wicri:regionArea><wicri:noRegion>Guangdong 510630</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Ling" sort="Chen, Ling" uniqKey="Chen L" first="Ling" last="Chen">Ling Chen</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Neurology, the First Affiliated Hospital of Sun Yat‐sen University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Zhang, June" sort="Zhang, June" uniqKey="Zhang J" first="June" last="Zhang">June Zhang</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>School of Nursing, Sun Yat‐sen University, 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type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Wang, Qing" sort="Wang, Qing" uniqKey="Wang Q" first="Qing" last="Wang">Qing Wang</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Neurology, the Third Affiliated Hospital of Sun Yat‐sen University, Guangzhou</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Meifen Zhang, School of Nursing, Sun Yat‐sen University, 76 Zhongshan Road II, Guangzhou, Guangdong 510080, People's Republic of ChinaQing Wang, Department of Neurology, Director of Neurological Research Laboratory, The Third Affiliated Hospital of Sun Yat‐Sen University, 600 Tianhe Road, Guangzhou, Guangdong 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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2010-12-15">2010-12-15</date><biblScope unit="volume">25</biblScope><biblScope unit="issue">16</biblScope><biblScope unit="page" from="2740">2740</biblScope><biblScope unit="page" to="2746">2746</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">78AFA2E7735BEA817795DC164F7B6B5CFAF4A39F</idno><idno type="DOI">10.1002/mds.23368</idno><idno type="ArticleID">MDS23368</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Hr‐QoL</term><term>NMS</term><term>PDQ‐39</term><term>Parkinson's disease</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We performed a cross‐sectional study of 82 Chinese patients with Parkinson's disease (PD) enrolled during an 18‐month period using a clinical interview to assess the prevalence of nonmotor symptoms (NMS), the association with disease severity and motor status, and the impact on patients' health‐related quality of life (Hr‐QoL). The patients' NMS, Hr‐QoL, disease severity, and motor status were assessed by the Nonmotor Symptoms Scale (NMSS), the 39‐item Parkinson's Disease Questionnaire (PDQ‐39), the modified Hoehn and Yahr staging scale (H&Y) and the Unified Parkinson's Disease Rating Scale part III (UPDRS III), respectively. We found that 100% of patients with PD presented with NMS. The NMSS significantly correlated with disease duration (Spearman's rS = 0.276, P = 0.012), H&Y (rS = 0.230, P = 0.038), and UPDRS III (rS = 0.350, P = 0.001). Similarly, the PDQ‐39 SI significantly associated with the disease duration (rS = 0.258, P = 0.019), H&Y (rS = 0.340, P = 0.002), and UPDRS III (rS = 0.453, P < 0.001). NMS domains that influenced the PDQ‐39 SI were sleep/fatigue, mood, gastrointestinal, urinary, and miscellaneous symptoms. This strongly suggested that the five domains played a key role in the manifestation of Hr‐QoL. NMSS explains more of the variability in Hr‐QoL than UPDRS III, when both are the model (stepwise multiple linear regression analysis R2 change, 47.8% vs. 5.87%, respectively). Therefore, these findings demonstrate that NMS are independently and negatively associated with Hr‐QoL in PD and that improving NMS should be viewed as an important part in the management of PD. © 2010 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Guangdong</li></region><settlement><li>Jiangmen</li></settlement></list><tree><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Li, Huijuan" sort="Li, Huijuan" uniqKey="Li H" first="Huijuan" last="Li">Huijuan Li</name></region><name sortKey="Chen, Ling" sort="Chen, Ling" uniqKey="Chen L" first="Ling" last="Chen">Ling Chen</name><name sortKey="Hu, Ailing" sort="Hu, Ailing" uniqKey="Hu A" first="Ailing" last="Hu">Ailing Hu</name><name sortKey="Pei, Zhong" sort="Pei, Zhong" uniqKey="Pei Z" first="Zhong" last="Pei">Zhong Pei</name><name sortKey="Wang, Qing" sort="Wang, Qing" uniqKey="Wang Q" first="Qing" last="Wang">Qing Wang</name><name sortKey="Wang, Qing" sort="Wang, Qing" uniqKey="Wang Q" first="Qing" last="Wang">Qing Wang</name><name sortKey="Zhang, June" sort="Zhang, June" uniqKey="Zhang J" first="June" last="Zhang">June Zhang</name><name sortKey="Zhang, Meifen" sort="Zhang, Meifen" uniqKey="Zhang M" first="Meifen" last="Zhang">Meifen Zhang</name><name sortKey="Zhang, Meifen" sort="Zhang, Meifen" uniqKey="Zhang M" first="Meifen" last="Zhang">Meifen Zhang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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